Zika, Dengue and Chikungunya Panel

Zika, Dengue and Chikungunya Panel

Tropical Infections

Regulatory Status: LDT

Panel to detect Zika virus, Dengue serotypes I, II, III, IV and Chikungunya virus from plasma/serum.

Available from Aug 2018.

 

Zika virus is a member of the Flaviviridae family, first isolated in 1947 from a sentinel monkey in the Zika forest in Uganda.  The first known Zika virus outbreak occurred in 2007 on the island of Yap in the western Pacific.  It has since spread around the world: The virus strains that emerged in the Pacific, Americas, Africa (Cape Verde), and southeast Asia (Singapore) were all from the Asian lineage. Phylogenetic studies suggest that Zika virus was probably imported to Brazil from the Pacific, and to Cape Verde from Brazil. The outbreak in Singapore was caused by a strain closely related to the strain that had previously circulated in Asia before 2007, and was not the consequence of a new introduction from the Pacific or Americas.

Zika diagnosis is based on molecular detection of the Zika virus RNA from blood or urine.  The virus can be detected only briefly in plasma or serum during acute phase of the infection.

Reference:

Baud et.al. 2017, The Lancet, 390(10107):2099-2109