Zika virus

Zika virus

Tropical Infections

Regulatory Status: CE-IVD, LDT

Detection of Zika virus from plasma or serum.

 

Zika virus is a member of the Flaviviridae family, first isolated in 1947 from a sentinel monkey in the Zika forest in Uganda.  The first known Zika virus outbreak occurred in 2007 on the island of Yap in the western Pacific.  It has since spread around the world: The virus strains that emerged in the Pacific, Americas, Africa (Cape Verde), and southeast Asia (Singapore) were all from the Asian lineage. Phylogenetic studies suggest that Zika virus was probably imported to Brazil from the Pacific, and to Cape Verde from Brazil. The outbreak in Singapore was caused by a strain closely related to the strain that had previously circulated in Asia before 2007, and was not the consequence of a new introduction from the Pacific or Americas.

Symptoms include mild fever, heachache, rash, arthralgia and conjunctivitis. In 2016, reports of infections in adults have been linked to Guillain–Barré syndrome and mother-to- child transmission during pregnancy can cause microcephaly and other brain malformations in some babies.

Zika diagnosis is based on molecular detection of the Zika virus RNA from blood or urine.  The virus can be detected only briefly in plasma or serum during acute phase of the infection.

Reference:

Baud et.al. 2017, The Lancet, 390(10107):2099-2109 

 

SAMPLE REQUIREMENT

Minimum volume: 2 mL of serum or plasma